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Zoological Science



Zoological Science 10(5):763-772. October 1993
10.34425/zs001140


Eedotfaelin-1 Causes Aggregation of Pigment in Teleostean Melanophores

Fujii Ryozo, Tanaka Yukiko, Hayashi Hiroshi

Department of Biomolecular Science, Faculty of Science, Toho University, Miyama, Funabashi, Chiba 274, Japan
1To whom reprint requests should be addressed.

In many species of teleosts, and in zebrafish (Brachydanio rerio) in particular, endothelin-1 (ET-1) caused aggregation of pigment within melanophores in a dose-dependent manner. ET-1 appeared to act directly on the melanophores since denervated melanophores responded to the peptide quite similarly to the normally innervated cells. Alpha-adrenergic blockers, namely, phentolamine and tolazoline, and a muscarinic cholinergic blocker, scopolamine, did not interfere with the action of ET-1 on melanophores. Contrary to our expectations, BQ-123, an inhibitor of mammalian ET-1 receptors (ETA receptors), did not block the action of ET-1 on melanophores. Presumably, teleostean ET receptors have very different pharmacological characteristics from those of mammalian species. In many fishes, ET may be involved in the subtle and delicate modification of hues and patterns of the integument that are associated with their elaborate and effective chromatic strategies for survival.

Received: May 27, 1993 ;   Acccepted: June 14, 1993

Keywords: 



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